Title
Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis
DOI
10.17077/etd.dbmqnenp
Document Type
Thesis
Date of Degree
Summer 2010
Degree Name
MS (Master of Science)
Degree In
Oral Science
First Advisor
Kim A. Brogden
First Committee Member
Georgia K Johnson
Second Committee Member
Paula L Weistroffer
Third Committee Member
Jeffrey A Banas
Abstract
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.
Keywords
alpha-defensins, beta-defensins, Periodontal Disease, periodontitis, Porphyromonas gingivalis
Pages
x, 99 pages
Bibliography
Includes bibliographical references (pages 55-65).
Copyright
Copyright 2010 Matthew David Carlisle
Recommended Citation
Carlisle, Matthew David. "Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis." MS (Master of Science) thesis, University of Iowa, 2010.
https://doi.org/10.17077/etd.dbmqnenp.