Document Type

Thesis

Date of Degree

Summer 2010

Degree Name

MS (Master of Science)

Degree In

Oral Science

First Advisor

Kim A. Brogden

First Committee Member

Georgia K Johnson

Second Committee Member

Paula L Weistroffer

Third Committee Member

Jeffrey A Banas

Abstract

Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.

Keywords

alpha-defensins, beta-defensins, Periodontal Disease, periodontitis, Porphyromonas gingivalis

Pages

x, 99 pages

Bibliography

Includes bibliographical references (pages 55-65).

Copyright

Copyright 2010 Matthew David Carlisle

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