Title
Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis
DOI
10.17077/etd.dbmqnenp
Document Type
Thesis
Date of Degree
Summer 2010
Degree Name
MS (Master of Science)
Degree In
Oral Science
First Advisor
Brogden, Kim A.
First Committee Member
Johnson, Georgia K.
Second Committee Member
Weistroffer, Paula L.
Third Committee Member
Banas, Jeffrey A.
Abstract
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.
Keywords
alpha-defensins, beta-defensins, Periodontal Disease, periodontitis, Porphyromonas gingivalis
Pages
x, 99 pages
Bibliography
Includes bibliographical references (pages 55-65).
Copyright
Copyright 2010 Matthew David Carlisle
Recommended Citation
Carlisle, Matthew David. "Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis." MS (Master of Science) thesis, University of Iowa, 2010.
https://doi.org/10.17077/etd.dbmqnenp