DOI

10.17077/etd.89nm-lx8g

Document Type

Dissertation

Date of Degree

Spring 2019

Degree Name

PhD (Doctor of Philosophy)

Degree In

Pharmacology

First Advisor

Grobe, Justin L.

First Committee Member

Fisher, Rory A.

Second Committee Member

Rahmouni, Kamal

Third Committee Member

Santillan, Mark K.

Fourth Committee Member

Sigmund, Curt D.

Abstract

Preeclampsia is a devastating disorder of pregnancy characterized by high blood pressure, proteinuria, headache, renal glomerular endotheliosis, multi-organ system failure, and fetal and maternal demise. As reviewed in Chapter I, not much is known about the pathogenesis of preeclampsia, contributing to a lack of biomarkers and treatments for the disease. In Chapter II, we review arginine vasopressin, a circulating neuropeptide hormone with important fluid balance and cardiovascular actions. Vasopressin binds to numerous receptors throughout the body to elicit its effects and is associated with various disease states. In Chapter III, we discuss evidence for vasopressin as an etiology of preeclampsia. Specifically, that vasopressin secretion is elevated very early in pregnancies affected by preeclampsia and infusion of vasopressin into pregnant C57BL/6J mice causes physiological features similar to those seen in preeclampsia. In Chapter IV, we show that vasopressin administration during mouse pregnancy models specific subtypes of preeclampsia through time- and receptor-specific mechanisms. The role of angiotensin 1a receptors on vasopressin-producing cells in fluid homeostasis is shown in Chapter V and their role in metabolism is depicted in Chapter VI. Overall, we conclude that vasopressin is an important mediator of features of preeclampsia and that angiotensin 1a receptors on vasopressin-producing cells are important for normal fluid homeostasis.

Keywords

antidiuretic hormone, AVP, hypertension, preeclampsia, pregnancy, vasopressin

Pages

xi, 165 pages

Bibliography

Includes bibliographical references (pages 144-165).

Copyright

Copyright © 2019 Jeremy Anton Sandgren

Included in

Pharmacology Commons

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