Date of Degree
MS (Master of Science)
Staley, Robert N
First Committee Member
Second Committee Member
Third Committee Member
Purpose: The purpose of this study is to evaluate the effectiveness of MI Paste Plus™ in increasing remineralization and improving the esthetic appearance of white spot lesions in patients who have been treated with fixed orthodontic appliances. Material and Methods: A total of twelve subject participants aged twelve to twenty years were selected in this pilot study. The six treatment group subjects were treated with MI Paste PlusTM every three weeks in-office (4 applications) and via invisible retainer every night for a total of 12 weeks. The in-office application consisted of a 1 minute 35% phosphoric acid and a 5 minute MI Paste PlusTM contact time. At home, the subjects went about their routine oral hygiene practices, but added MI Paste PlusTM to their invisible retainer before bedtime which was worn throughout the night. Photographs and quantitative light-induced fluorescence (QLF) were used to calculate white spot lesion area and ∆F values respectively. Results: A significant difference was found in the control group for the area of the white spot lesion in antimere teeth #6 and #11. When analyzing the white spot lesion area in the treatment group, significant differences were found in tooth #6, antimere teeth #6 and #11, antimere teeth #8 and #9, as well as all teeth. ∆F values for all teeth in both the control and treatment groups were significant. Conclusion: In-office and at home treatment with MI Paste Plus™ showed a statistically significant reduction in photographic lesion area when compared to controls. Both MI Paste Plus™ and a fluoride toothpaste will provide some remineralization of white spot lesions.
fluoride, MI Paste Plus, orthodontics, remineralization
viii, 70 pages
Includes bibliographical references (pages 65-70).
Copyright 2011 Sarah Clark
Clark, Sarah Elizabeth. "Remineralization effectiveness of MI Paste Plus - a clinical pilot study." MS (Master of Science) thesis, University of Iowa, 2011.