DOI

10.17077/etd.9hqq3ok6

Document Type

Thesis

Date of Degree

Spring 2011

Degree Name

MS (Master of Science)

Degree In

Orthodontics

First Advisor

Lina M. Moreno

First Committee Member

Deborah V Dawson

Second Committee Member

Seth M Weinberg

Third Committee Member

Thomas E Southard

Fourth Committee Member

Andrew Lidral

Abstract

The purpose of this work is to study phenotypic craniofacial traits of unaffected parents of individuals with nonsyndromic cleft lip with or without palate (NSCL/P). In order to evaluate these craniofacial traits, three dimensional photographs were obtained and landmarked to compare the sample of unaffected parents with a control sample. The sample was comprised of 40 unaffected fathers, 25 control males, 84 unaffected mothers, and 34 control females. Twenty-four three-dimensional landmarks were exported for analysis for each subject. For the purposes of this study, nine euclidean distances were subjected to a discriminant function analysis to evaluate their ability to discriminate between an unaffected parent and a control. In both the male and female analysis, certain craniofacial measurements correctly and significantly discriminated between unaffected parents and controls. It appears that certain facial traits are subclinical markers for enhanced genetic susceptibility to nonsyndromic cleft lip with or without palate.

Keywords

Cleft Lip, Soft Tissue Captures, Stereophotogrammetry, Subphenotype, Three Dimensional, Unaffected

Pages

viii, 74 pages

Bibliography

Includes bibliographical references (pages 70-74).

Copyright

Copyright 2011 David Defay

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