DOI
10.17077/etd.9hqq3ok6
Document Type
Thesis
Date of Degree
Spring 2011
Degree Name
MS (Master of Science)
Degree In
Orthodontics
First Advisor
Moreno, Lina M
First Committee Member
Dawson, Deborah V
Second Committee Member
Weinberg, Seth M
Third Committee Member
Southard, Thomas E
Fourth Committee Member
Lidral, Andrew
Abstract
The purpose of this work is to study phenotypic craniofacial traits of unaffected parents of individuals with nonsyndromic cleft lip with or without palate (NSCL/P). In order to evaluate these craniofacial traits, three dimensional photographs were obtained and landmarked to compare the sample of unaffected parents with a control sample. The sample was comprised of 40 unaffected fathers, 25 control males, 84 unaffected mothers, and 34 control females. Twenty-four three-dimensional landmarks were exported for analysis for each subject. For the purposes of this study, nine euclidean distances were subjected to a discriminant function analysis to evaluate their ability to discriminate between an unaffected parent and a control. In both the male and female analysis, certain craniofacial measurements correctly and significantly discriminated between unaffected parents and controls. It appears that certain facial traits are subclinical markers for enhanced genetic susceptibility to nonsyndromic cleft lip with or without palate.
Keywords
Cleft Lip, Soft Tissue Captures, Stereophotogrammetry, Subphenotype, Three Dimensional, Unaffected
Pages
viii, 74 pages
Bibliography
Includes bibliographical references (pages 70-74).
Copyright
Copyright 2011 David Defay
Recommended Citation
Defay, David Kay. "3D facial analysis: unaffected parents of individuals with cleft lip/palate." MS (Master of Science) thesis, University of Iowa, 2011.
https://doi.org/10.17077/etd.9hqq3ok6