Major Department

Health and Human Physiology

College

College of Liberal Arts & Sciences

Degree

BS (Bachelor of Science)

Session and Year of Graduation

Spring 2019

Honors Major Advisor

Lucas Carr

Thesis Mentor

Ryan LaLumiere, Victória Müller Ewald

Abstract

Cocaine addiction is a prevalent and substantial problem. It is very difficult for cocaine-addicted individuals to receive treatment, avoid relapse, and go into full remission. Animal models of cocaine taking can be used to study different facets of this disease. One such model is cocaine self-administration. Although self-administration is a widely used model in the field of drug-addiction biology (Müller Ewald V., Lalumiere R., 2017), its influence on rat-specific characteristics such as anxiety and craving is not clear. In this experiment, we sought to correlate drug-taking levels during self-administration with measures of anxiety-like behaviors and cocaine craving. Male Sprague-Dawley rats (n=21) were implanted with intrajugular catheters and underwent cocaine self-administration. Rats then underwent two tests, before and after withdrawal, to serve as a measure of cocaine craving. Our results suggest that levels of cocaine taking during cocaine self-administration does not appear to impact levels of cocaine craving during periods of withdrawal or levels of anxiety-like behaviors of rats during experimental studies. Overall, this strengthens the self-administration model and its ability to study the neurobiology of addiction.

Total Pages

10

Copyright

Copyright © 2019 Jesse Gray

COinS
 

URL

https://ir.uiowa.edu/honors_theses/295