Major Department

Health and Human Physiology


College of Liberal Arts & Sciences


BS (Bachelor of Science)

Session and Year of Graduation

Spring 2017

Honors Major Advisor

Gary Pierce

Thesis Mentor

Amy Sindler


Infants born prematurely are at an increased risk of cardiovascular diseases as they age. Oxygen supplementation during this critical window is necessary to sustain life because the lungs are under-developed, however, it is thought that high oxygen exposure may generate excessive superoxide contributing to oxidative stress. Using a rat model of prematurity, we tested the hypothesis that perinatal oxygen supplementation would increase aortic stiffness due to oxidative stress within the arterial wall. Immediately upon birth, 20 Sprague-Dawley pup rats were placed into environmental chambers with either 21% (control) or 80% oxygen (experimental) for eight days. All rats were aged until ~12 months, and blood pressure and pulse wave velocity (PWV) were measured. PWV was significantly higher in rats that were exposed to 80% oxygen after birth (371 ±13.25 vs 487 ± 27.84, p


vascular, dysfunction, prematurity, oxygen, supplementation

Total Pages

17 pages


Copyright © 2017 Amanda Owens