Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

Can Respir J

Journal/Book/Conference Title

Canadian Respiratory Journal

DOI of Published Version


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End Page


Total Pages



We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation. We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia. We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD. We performed metabolomics analysis using NMR. We constructed partial least squares discriminant analysis (PLS-DA) models to distinguish metabolic profiles. Serum (, R2 = 0.397, Q2 = 0.058) and urine metabolic profiles (, R2 = 0.419, Q2 = 0.142) were significantly different between the four diagnosis groups by PLS-DA. After excluding stable COPD patients, the metabolomes of the various respiratory failure groups did not cluster separately in serum (, R2 = 0.631, Q2 = 0.246) or urine (, R2 = 0.602, Q2 = −0.134). However, several metabolites in the serum were reduced in patients with COPD exacerbation and pneumonia. We did not find a metabolic profile unique to COPD exacerbation, but we were able to clearly and reliably distinguish stable COPD patients from patients with respiratory failure in both serum and urine.


OAfund, COPD

Granting or Sponsoring Agency

Fairview Critical Care Program

Journal Article Version

Version of Record

Published Article/Book Citation

Canadian Respiratory Journal, vol. 2017, Article ID 9480346, 9 pages, 2017.


Copyright (c) 2017 Spyridon Fortis et al

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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.