Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

Cancer Med

Journal/Book/Conference Title

Cancer Medicine

PubMed ID


DOI of Published Version


Start Page


End Page


Total Pages

6 pages


Brain metastasis (BM) in patients with breast cancer is a catastrophic event that results in poor prognosis. Identification of prognostic factors associated with breast cancer brain metastases (BCBM) could help to identify patients at risk. The aim of this study was to assess clinical characteristics, prognostic factors, and survival of patients with BCBM who had craniotomy and resection in a series of patients treated with modern multimodality therapy. We analyzed 42 patients with BCBM who underwent resection. Patients were diagnosed with breast cancer between April 1994 and May 2010. Cox proportional hazards regression was selected to describe factors associated with time to BM, survival from the date of first recurrence, and overall survival (OS). Median age was 51 years (range 24-74). Median follow-up was 4.2 years (range 0.6-18.5). The proportion of the biological subtypes of breast cancer was ER+/HER2- 25%, ER+/HER2+ 15%, ER-/HER2+ 30%, and ER-/HER2- 30%. Median OS from the date of primary diagnosis was 5.74 years. Median survival after diagnosis of BM was 1.33 years. In multivariate Cox regression analyses, stage was the only factor associated with shorter time to the development of BM (P = 0.033), whereas age was the only factor associated with survival from the date of recurrence (P = 0.027) and with OS (P = 0.037). Stage at primary diagnosis correlated with shorter time to the development of BM, while age at diagnosis was associated with shorter survival in BCBM. None of the other clinical factors had influence on survival.


OAfund, Brain metastasis, breast cancer, craniotomy, pronostic factors, survival

Journal Article Version

Version of Record

Published Article/Book Citation

Cancer Medicine, 2015, 4(7):989-994. DOI: 10.1002/cam4.439


Copyright © 2015, Jose Pablo Leone, Adrian V. Lee, and Adam M. Brufsky.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.