Document Type

Article

Peer Reviewed

1

Publication Date

7-20-2015

NLM Title Abbreviation

Viruses

Journal/Book/Conference Title

Viruses

PubMed ID

26205405

DOI of Published Version

10.3390/v7072810

Abstract

Exosomes are membranous nanovesicles of endocytic origin that carry host and pathogen derived genomic, proteomic, and lipid cargos. Exosomes are secreted by most cell types into the extracellular milieu and are subsequently internalized by recipient cells. Upon internalization, exosomes condition recipient cells by donating their cargos and/or activating various signal transduction pathways, consequently regulating physiological and pathophysiological processes. The role of exosomes in viral pathogenesis, especially human immunodeficiency virus type 1 [HIV-1] is beginning to unravel. Recent research reports suggest that exosomes from various sources play important but different roles in the pathogenesis of HIV-1. From these reports, it appears that the source of exosomes is the defining factor for the exosomal effect on HIV-1. In this review, we will describe how HIV-1 infection is modulated by exosomes and in turn how exosomes are targeted by HIV-1 factors. Finally, we will discuss potentially emerging therapeutic options based on exosomal cargos that may have promise in preventing HIV-1 transmission.

Keywords

extracellular vesicle, nanoparticle, exosome, semen, seminal plasma, HIV-1, murine AIDS, OAfund

Journal Article Version

Version of Record

Published Article/Book Citation

Viruses 2015, 7, 4093-4118; doi:10.3390/v7072810

Rights

© 2015 by the authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Included in

Microbiology Commons

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URL

https://ir.uiowa.edu/microbiology_pubs/4