Document Type

Article

Peer Reviewed

1

Publication Date

12-7-2015

NLM Title Abbreviation

Immunity, Inflammation and Dis

Journal/Book/Conference Title

Immunity, Inflammation and Disease

DOI of Published Version

10.1002/iid3.92

Abstract

Host cells respond to viral infections by activating immune response genes that are not only involved in inflammation, but may also predispose cells to cancerous transformation. One such gene is BST-2, a type II transmembrane protein with a unique topology that endows it tethering and signaling potential. Through this ability to tether and signal, BST-2 regulates host response to viral infection either by inhibiting release of nascent viral particles or in some models inhibiting viral dissemination. However, despite its antiviral functions, BST-2 is involved in disease manifestation, a function linked to the ability of BST-2 to promote cell-to-cell interaction. Therefore, modulating BST-2 expression and/or activity has the potential to influence course of disease.

Keywords

OAfund, Antagonists, breast cancer, BST-2, cancer, HIV-1, malignancies, tethering, viruses

Journal Article Version

Version of Record

Published Article/Book Citation

Mahauad-Fernandez, W. D. and Okeoma, C. M. (2016), The role of BST-2/Tetherin in host protection and disease manifestation. Immunity, Inflammation and Dis, 4: 4–23. doi: 10.1002/iid3.92

Rights

© 2015 The Authors

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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Microbiology Commons

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URL

https://ir.uiowa.edu/microbiology_pubs/5