Document Type
Article
Peer Reviewed
1
Publication Date
12-7-2015
NLM Title Abbreviation
Immunity, Inflammation and Dis
Journal/Book/Conference Title
Immunity, Inflammation and Disease
DOI of Published Version
10.1002/iid3.92
Start Page
4
End Page
23
Abstract
Host cells respond to viral infections by activating immune response genes that are not only involved in inflammation, but may also predispose cells to cancerous transformation. One such gene is BST-2, a type II transmembrane protein with a unique topology that endows it tethering and signaling potential. Through this ability to tether and signal, BST-2 regulates host response to viral infection either by inhibiting release of nascent viral particles or in some models inhibiting viral dissemination. However, despite its antiviral functions, BST-2 is involved in disease manifestation, a function linked to the ability of BST-2 to promote cell-to-cell interaction. Therefore, modulating BST-2 expression and/or activity has the potential to influence course of disease.
Keywords
OAfund, Antagonists, breast cancer, BST-2, cancer, HIV-1, malignancies, tethering, viruses
Journal Article Version
Version of Record
Published Article/Book Citation
Mahauad-Fernandez, W. D. and Okeoma, C. M. (2016), The role of BST-2/Tetherin in host protection and disease manifestation. Immunity, Inflammation and Dis, 4: 4–23. doi: 10.1002/iid3.92
Rights
© 2015 The Authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
URL
http://ir.uiowa.edu/microbiology_pubs/5