Saitohin and APOE polymorphisms influence cognition and function in persons with advanced Alzheimer Disease
NLM Title Abbreviation
Dement Geriatr Cogn Disord
Dementia and geriatric cognitive disorders
DOI of Published Version
BACKGROUND/AIMS: Alzheimer disease (AD) is characterized by variability in the onset and progression of cognitive, functional and behavioral symptoms. The purpose of this study was to identify genetic correlates of symptom variability in persons with moderate-to-advanced AD. METHODS: Repeated measures of cognition, function and behavior were collected from institutionalized persons with AD over 12 months. Candidate genes were assayed. RESULTS: Single polymorphisms within the saitohin and APOE genes were associated with increased cognitive impairment and functional dependence. The APOE-epsilon4 allele was associated with increased baseline physical agitation. CONCLUSION: The development of predictive profiles for the clinical symptoms of AD may increase our ability to identify clinical subgroups for more targeted intervention.
Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease/complications/genetics, Apolipoprotein E4/genetics, Cognition Disorders/complications/genetics, Female, Humans, Male, Polymorphism, Single Nucleotide, Severity of Illness Index, tau Proteins/genetics
Published Article/Book Citation
Dementia and geriatric cognitive disorders, 32:2 (2011) pp.94-102. DOI:10.1159/000329542;.