Title

Regionally Selective Atrophy of Subcortical Structures in Prodromal HD as Revealed by Statistical Shape Analysis.

Document Type

Article

Peer Reviewed

1

Publication Date

3-1-2014

Journal/Book/Conference Title

Human Brain Mapping

PubMed ID

23281100

DOI of Published Version

10.1002/hbm.22214

Abstract

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

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URL

https://ir.uiowa.edu/nursing_pubs/2008