Integrating molecular genetics analyses into clinical research

Document Type


Peer Reviewed


Publication Date


NLM Title Abbreviation

Biol Res Nurs

Journal/Book/Conference Title

Biological research for nursing

PubMed ID


DOI of Published Version



The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable to molecular genetics approaches. Both human and animal model research suggests that differences in these responses may be related, in part, to variation in the genes that modulate sensation and behavior. The authors are currently managing a large cross-disciplinary research effort to identify child characteristics, including genotypes, that predict the degree of distress displayed by children following a painful medical procedure (i.e., IV insertion). The purpose of this article is to describe the strategies used to integrate molecular genetics methods into this project. The authors discuss the steps needed to complete this process, including (a) establishing a collaboration with genetics researchers and laboratory facilities, (b) developing and implementing a plan to manage biologic samples, and (c) incorporating genetics into the informed consent process.


Child, Child Behavior, Child Psychology, Child, Preschool, Clinical Nursing Research/organization & administration, Consent Forms, Cooperative Behavior, Genetic Privacy, Genetic Research, Genetics, Medical/organization & administration, Genotype, Humans, Interdisciplinary Communication, Interprofessional Relations, Molecular Biology/organization & administration, Mouth Mucosa/cytology, Pain/genetics/physiopathology/prevention & control/psychology, Parents/education, Planning Techniques, Polymerase Chain Reaction, Randomized Controlled Trials as Topic, Research Design, Specimen Handling

Published Article/Book Citation

Biological research for nursing, 8:1 (2006) pp.67-77. DOI:10.1177/1099800406289909.

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