Saline for peripheral intravenous locks in neonates: evaluating a change in practice
NLM Title Abbreviation
DOI of Published Version
PURPOSE: To evaluate the efficacy of saline versus 10 units/ml heparin for peripheral i.v. flushes in neonates. DESIGN: A nonexperimental group design was used to compare the longevity of heparin and saline i.v. locks. A research utilization method was chosen to increase the study power while simultaneously implementing a practice change and evaluating the outcomes. Power analysis showed that a sample size of approximately 120 per group was needed to decrease the risk of beta error to 0.1. SAMPLE: Subjects included neonates in the Special Care Nurseries at a Level III large midwestern university teaching hospital. Data were collected from a convenience sample of 123 neonates receiving 10 units/ml heparin flush into a peripheral i.v. Practice was then changed to preservative-free normal saline, and data collection continued for 117 neonates. MAIN OUTCOME VARIABLE: I.v. catheter longevity. RESULTS: There was no significant statistical difference in i.v. catheter longevity between i.v. locks flushed with 10 units/ml heparin and those flushed with normal saline. Patient weight accounted for a significant proportion of the variance in i.v. catheter life.
Catheterization, Peripheral/adverse effects/methods, Evaluation Studies as Topic, Female, Heparin/pharmacology, Humans, Infant, Newborn, Infusions, Intravenous/nursing, Intensive Care Units, Neonatal, Male, Monitoring, Physiologic/nursing, Neonatal Nursing/methods, Probability, Prospective Studies, Reference Values, Sensitivity and Specificity, Sodium Chloride/pharmacology
Published Article/Book Citation
Neonatal network, 19:2 (2000) pp.19-24.