Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology

Rene' Martin, University of Iowa
E. V. Entchev
T. V. Kurzchalia
H. J. Knolker


Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.