Title

MtDNA variation in the Altai-Kizhi population of southern Siberia: a synthesis of genetic variation

Document Type

Article

Peer Reviewed

1

Publication Date

8-1-2006

NLM Title Abbreviation

Hum Biol

Journal/Book/Conference Title

Human biology

PubMed ID

17278622

DOI of Published Version

10.1353/hub.2006.0055

Start Page

477

End Page

494

Abstract

The native peoples of Gorno Altai in southern Siberia represent a genetically diverse population and have been of great interest to anthropological genetics. In particular, the southern Altaian population is argued to be the best candidate for the New World ancestral population. In this study we sampled Altai-Kizhi from the southern Altaian village of Mendur-Sokkon, analyzed mtDNA RFLP markers and HVS-I sequences, and compared the results to other published mtDNA data from Derenko et al. (2003) and Shields et al. (1993) encompassing the same region. Because each independent study uses different sampling techniques in characterizing gene pools, in this paper we explore the accuracy and reliability of evolutionary studies on human populations. All the major Native American haplogroups (A, B, C, and D) were identified in the Mendur-Sokkon sample, including a single individual belonging to haplogroup X. The most common mtDNA lineages are C (35.7%) and D (13.3%), which is consistent with the haplogroup profiles of neighboring Siberian groups. The Mendur-Sokkon sample exhibits depressed HVS-I diversity values and neutrality test scores, which starkly differs from the Derenko et al. (2003) data set and more closely resembles the results for neighboring south Siberian groups. Furthermore, the multidimensional scaling plot of DA genetic distances does not cluster the Altai samples, showing different genetic affinities with various Asian groups. The findings underscore the importance of sampling strategy in the reconstruction of evolutionary history at the population level.

Keywords

Asian Continental Ancestry Group/genetics, Base Pair Mismatch, DNA, Mitochondrial/analysis/genetics, Evolution, Molecular, Gene Pool, Genetic Variation, Genetics, Population, Haplotypes, Humans, Indians, North American/genetics, Phylogeny, Polymorphism, Restriction Fragment Length, Siberia/ethnology

Published Article/Book Citation

Human biology, 78:4 (2006) pp.477-494.

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URL

https://ir.uiowa.edu/obgyn_pubs/347