Title

Plasmapheresis for the treatment of repeated early pregnancy wastage associated with anti-P

Document Type

Article

Peer Reviewed

1

Publication Date

9-1-1985

NLM Title Abbreviation

Obstet Gynecol

Journal/Book/Conference Title

Obstetrics and gynecology

PubMed ID

4022518

Start Page

57S

End Page

60S

Abstract

It has been proposed that the blood group antibody, anti-P, produced by p or Pk individuals may cause abortion early in pregnancy. The authors have studied and successfully treated a Pk woman with anti-P who had 13 consecutive first-trimester miscarriages. Anti-P was implicated as the cause of repeated pregnancy loss after extensive clinical, endocrinologic, immunologic, and chromosomal evaluations. To remove P blood group antibodies, plasmapheresis was begun at five weeks' gestation during the 14th pregnancy with one plasma volume exchange two to three times per week. This therapy resulted in a reduction in the titer of anti-P, and the patient was delivered of a viable female infant after 33 weeks' gestation. The management and outcome indicate that habitual abortion presumably due to anti-P can be successfully treated with plasmapheresis. This case provides additional evidence that anti-P is responsible for abortions in p or Pk women, and that these abortions are immunologically mediated.

Keywords

Abortion, Habitual/immunology/prevention & control, Adult, Antibodies/analysis, Blood Group Antigens/immunology, Female, Humans, P Blood-Group System/genetics/immunology, Phenotype, Plasma Exchange, Plasmapheresis/adverse effects, Pregnancy

Published Article/Book Citation

Obstetrics and gynecology, 66:3 Suppl (1985) pp.57S-60S.

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URL

https://ir.uiowa.edu/obgyn_pubs/576