Title

The influence of aspirin on the course of induced midtrimester abortion

Document Type

Article

Peer Reviewed

1

Publication Date

3-15-1976

NLM Title Abbreviation

Am J Obstet Gynecol

Journal/Book/Conference Title

American Journal of Obstetrics and Gynecology

PubMed ID

769555

DOI of Published Version

10.1016/0002-9378(76)90062-4

Start Page

607

End Page

610

Abstract

Prostaglandins appear to mediate the uterine contractions of abortion and labor, and aspirin has been shown to be an inhibitor of prostaglandin synthesis. In this double-blind, placebo-controlled, prospective, and randomized study, aspirin was administered orally in doses of 600 mg. every 6 hours to patients undergoing induced midtrimester abortions with hyperosmolar urea and oxytocin augmentation. The mean injection-abortion interval was significantly prolonged by aspirin in nulliparous patients (aspirin 32.3 +/- 3.3 hr. vs. placebo 21.5 +/- 3.5 hr.) and no aspirin-treated nullipara aborted in less than 18 hours. There was no significant difference between treatment groups in the mean injection-abortion interval in the multiparous patients at the dose of aspirin used. The effectiveness of aspirin in the prolongation of the injection-abortion interval has potential therapeutic implications for the treatment of premature labor.

Keywords

Abortion, Induced/adverse effects, Adolescent, Adult, Clinical Trials as Topic, Female, Humans, Obstetric Labor, Premature/drug therapy, Parity, Placebos, Pregnancy, Pregnancy Trimester, Second

Published Article/Book Citation

American Journal of Obstetrics and Gynecology, 124:6 (1976) pp.607-610.

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URL

https://ir.uiowa.edu/obgyn_pubs/603