Title

The role of oestrogen in follicular development.

Document Type

Article

Publication Date

8-1-1997

NLM Title Abbreviation

Mol Hum Reprod

Journal/Book/Conference Title

Molecular human reproduction

DOI of Published Version

10.1093/molehr/3.8.643

Start Page

643

End Page

645

Abstract

Most of our knowledge of ovarian physiology is based upon studies that have demonstrated functional oestrogen receptors in the ovaries of lower animal species. The presence of oestrogen receptors in primate granulosa cells has been questioned by some investigators. However, we have found oestrogen receptor messenger RNA in human granulosa cells by reverse transcriptase-PCR assay. Furthermore, using immortalized granulosa cell lines transfected with a plasmid containing an oestrogen response element, a functional oestrogen receptor was confirmed. These experiments strongly support the hypothesis that human granulosa cells express biologically active oestrogen receptor.

Keywords

Animals, Female, Granulosa Cells, Humans, Ovarian Follicle, Ovary, Plasmids, Polymerase Chain Reaction, Primates, RNA, Messenger, Receptors, Estrogen, Transcription, Genetic, Transfection

Published Article/Book Citation

Molecular human reproduction (1997) 3:8, pp. 643-645.

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URL

https://ir.uiowa.edu/obgyn_pubs/61