Title

An inhibitor of K+ channels modulates human endometrial tumor-initiating cells

Document Type

Article

Peer Reviewed

1

Publication Date

8-2-2011

NLM Title Abbreviation

Cancer Cell Int

Journal/Book/Conference Title

Cancer cell international

PubMed ID

21810252

DOI of Published Version

10.1186/1475-2867-11-25

Start Page

25

Abstract

BACKGROUND: Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer cell subpopulation, termed tumor initiating cells (TIC), are critical to cancer progression. RESULTS: A non-selective antagonist of multiple types of K+ channels, tetraethylammonium (TEA), was found to suppress colony formation in endometrial cancer cells via inhibition of putative TIC. The data also indicated that withdrawal of TEA results in a significant enhancement of tumorigenesis. When the TIC-enriched subpopulation was isolated from the endometrial cancer cells, TEA was also found to inhibit growth in vitro. CONCLUSIONS: These studies suggest that the activity of potassium channels significantly contributes to the progression of endometrial tumors, and the antagonists of potassium channels are candidate anti-cancer drugs to specifically target tumor initiating cells in endometrial cancer therapy.

Published Article/Book Citation

Cancer cell international (2011) 11:1, pp. 25-.

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URL

https://ir.uiowa.edu/obgyn_pubs/7