Title

Assessment of ovarian reserve with anti-Mullerian hormone: a comparison of the predictive value of anti-Mullerian hormone, follicle-stimulating hormone, inhibin B, and age

Document Type

Article

Peer Reviewed

1

Publication Date

8-1-2008

NLM Title Abbreviation

Am J Obstet Gynecol

Journal/Book/Conference Title

American Journal of Obstetrics and Gynecology

PubMed ID

18674663

DOI of Published Version

10.1016/j.ajog.2008.05.004

Start Page

202.e1

End Page

202.e8

Abstract

OBJECTIVE: The objective of this study was to evaluate basal anti-Mullerian hormone as a marker for ovarian responsiveness to fertility treatment. STUDY DESIGN: Frozen basal menstrual cycle day 3 serum samples were evaluated retrospectively for anti-Mullerian hormone, inhibin B, and follicle-stimulating hormone levels in 123 in vitro fertilization cycles (93 patients) and compared with in vitro fertilization records. RESULTS: Anti-Mullerian hormone values correlated the best with the number of retrieved oocytes (r = 0.539; P .05), luteinizing hormone (P > .05), and estradiol (r = -0.190; P .05), luteinizing hormone (P > .05), and estradiol (r = -0.190; P .05). Similarly, for the prediction of >or=15 retrieved oocytes, anti-Mullerian hormone had the largest area under the curve (0.80; P = .0001) relative to age (0.63; P = .02), follicle-stimulating hormone (0.64; P = .005), inhibin B (r = 0.57; P > .05), and estradiol (0.58; P > .05). CONCLUSION: Anti-Mullerian hormone correlates better than age, follicle-stimulating hormone, luteinizing hormone, inhibin B, and estradiol with the number of retrieved oocytes. Receiver operating characteristic curves estimated that anti-Mullerian hormone accurately predicts ovarian responsiveness to controlled ovarian stimulation with high sensitivity and specificity.

Keywords

Adult, Age Factors, Anti-Mullerian Hormone/blood, Female, Follicle Stimulating Hormone/blood, Humans, Immunoenzyme Techniques, Inhibins/blood, Luteinizing Hormone/blood, Oocyte Retrieval, Ovulation Induction, Predictive Value of Tests, ROC Curve, Retrospective Studies

Published Article/Book Citation

American Journal of Obstetrics and Gynecology, 199:2 (2008) pp.202.e1-202.e8.

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URL

https://ir.uiowa.edu/obgyn_pubs/948