Title

Endometrial response to unopposed estrogens remains unaltered in patients with chronic renal failure receiving hemodialysis

Document Type

Article

Peer Reviewed

1

Publication Date

1-1-1999

NLM Title Abbreviation

Gynecol Obstet Invest

Journal/Book/Conference Title

Gynecologic and obstetric investigation

PubMed ID

9852388

DOI of Published Version

10.1159/000010057

Start Page

26

End Page

28

Abstract

Most patients with chronic renal failure who are on maintenance hemodialysis are anovulatory and have menstrual abnormalities. This study was designed to determine the prevalence of organic causes of abnormal uterine bleeding in this group of patients exposed to unopposed estrogens. Eighteen patients with chronic renal failure and abnormal uterine bleeding underwent vacuum curettage. The histopathologic findings were compared with a group of 154 premenopausal women who had abnormal uterine bleeding without detectable organic causes. Excluding patients with secretory and atrophic endometrium, only 2 of 8 patients (25%) with chronic renal failure had endometrial lesions while 44 of 131 patients (33.6%) had either endometrial polyp, simple or atypical endometrial hyperplasia or endometrial carcinoma (p > 0.05). The uremic environment caused by chronic renal failure does not alter the endometrial responsiveness to unopposed estrogens and may lead to the development of endometrial lesions.

Keywords

Adult, Endometrial Neoplasms/complications, Endometrium/drug effects/pathology, Estrogens/adverse effects, Female, Humans, Kidney Failure, Chronic/complications/therapy, Menstruation Disturbances/etiology, Middle Aged, Polyps/complications, Renal Dialysis, Uterine Diseases/complications/pathology, Uterine Hemorrhage/etiology

Published Article/Book Citation

Gynecologic and obstetric investigation, 47:1 (1999) pp.26-28.

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URL

https://ir.uiowa.edu/obgyn_pubs/959