US Patent 5,231,174
United States Patent and Trademark Office
University of Iowa Research Foundation (Oakdale, IA, US)
The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'β-D-nucleosides and their derivatives where the base moiety has β-stereochemistry but is transposed from the normal 1'-position to the 2'-position and the carbohydrate moiety has the D-configuration at the 4'-position. These compounds are resistant towards hydrolytic cleavage of the glycosidic bond and are resistant to enzymatic deamination. They have potential in the treatment or prophylaxis of viral infections, particularly retroviral infections and especially AIDS.
Nair, Vasu 2'isodideoxy-β-D-nucleosides as stable antiviral agents. US Patent 5,231,174 filed February 27, 1992 and issued July 27, 1993. https://ir.uiowa.edu/patents/107