US Patent 5,234,922
United States Patent and Trademark Office
University of Iowa Research Foundation (Oakdale, IA, US)
Methods for the treatment of secretory diarrhea comprised of administering to a patient in need thereof, an effective amount of a CFTR chloride channel blocker or a potassium channel opener are disclosed. The CFTR chloride channel blocker is a sulfonylurea of the group consisting of tolbutamide, glibenclamide, and related analogs. The potassium channel opener is selected from the group consisting of diazoxide, lemakalim, and minoxidil sulfate.
Welsh, Michael J. and Sheppard, David N. Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea. US Patent 5,234,922 filed September 28, 1992 and issued August 10, 1993. https://ir.uiowa.edu/patents/108