Document Type

Patent

Patent Number

US Patent 5,242,801

Patent agency

United States Patent and Trademark Office

Publication Date

9-7-1993

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; Regents of the University of Minnesota (Minneapolis, MN)

Application Number

07/562,719

Date Filed

1990-08-06

Total Pages

12 pages

Abstract

The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.

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URL

https://ir.uiowa.edu/patents/109