Document Type

Patent

Patent Number

US Patent 5,308,752

Patent agency

United States Patent and Trademark Office

Publication Date

5-3-1994

Assignee

University of Iowa Research Foundation (Oakdale, IA, US)

Application Number

07/946,234

Date Filed

1992-09-14

Total Pages

23 pages

Abstract

Disclosed are methods for the diagnosis of autosomal muscular dystrophy through the analysis of muscle tissue using antibodies reactive with components of the dystrophin-glycoprotein complex. An experimental muscle tissue sample, treated if necessary to render components of the dystrophin-glycoprotein complex available for antibody binding, is contacted with an antibody which binds to a dystrophin-associated protein. The extent of antibody binding is determined, and compared to the extent of antibody binding to normal control tissue. A substantial reduction in the extent of binding to experimental tissue, as compared with normal control tissue, being diagnostic of autosomal muscular dystrophy. Among the autosomal muscular dystrophies which are detectable by the methods described herein are Fukuyama muscular dystrophy and severe childhood autosomal recessive muscular dystrophy.

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URL

https://ir.uiowa.edu/patents/119