US Patent 5,385,839
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The cloning of a eucaryotic promoter-regulatory region that functions preferentially in human cells is disclosed. The invention is exemplified by the cloning of a section of the human cytomegalovirus genome comprising a DNA sequence with regulatory and promoter signals and an initiation site for RNA synthesis. The fragment, termed the human cytomegalovirus (HCMV) promoter-regulatory sequence, was obtained from purified HCMV DNA.
Stinski, Mark F. Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter regulatory DNA sequence. US Patent 5,385,839 filed June 17, 1992 and issued January 31, 1995. https://ir.uiowa.edu/patents/128