Title

Purification of heparinase I, II, and III from Flavobacterium heparinum

Document Type

Patent

Patent Number

US Patent 5,389,539

Patent agency

United States Patent and Trademark Office

Publication Date

2-14-1995

Assignee

Massachusetts Institute of Technology (Cambridge, MA) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

07/983,367

Date Filed

1992-11-30

Total Pages

19 pages

Abstract

A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.

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URL

https://ir.uiowa.edu/patents/130