US Patent 5,391,579
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.
Baker, Max T. and Tinker, John H. Deuterated sevoflurane as an inhalational anesthetic. US Patent 5,391,579 filed June 14, 1993 and issued February 21, 1995. https://ir.uiowa.edu/patents/131