US Patent 5,403,711
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A method of detection of nucleic acid (DNA or RNA) target sequence in which such a sequence serves as a cofactor for a catalytic reaction in which a complementary, labeled nucleic acid probe is cleaved such that the target sequence is released intact and can repeatedly recycle through the reaction pathway, thereby providing signal amplification.
Walder, Joseph A. and Walder, Roxanne Y. Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved. US Patent 5,403,711 filed July 06, 1993 and issued April 04, 1995. https://ir.uiowa.edu/patents/133