US Patent 5,418,139
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Disclosed herein are methods for screening for primary cardiomyopathy. The methods are preferably immunological methods in which the level of binding of a monoclonal or polyclonal antibody to a 50 kD glycoprotein component of a mammalian muscle tissue is determined. This level of binding is compared to the level of binding observed when non-dystrophic tissue is treated in an otherwise identical manner. A substantial reduction in the level of binding to the 50 kD glycoprotein in the experimental mammalian muscle tissue has been determined to be a screen for primary cardiomyopathy.
Campbell, Kevin P. Method for screening for cardiomyopathy. US Patent 5,418,139 filed February 10, 1993 and issued May 23, 1995. https://ir.uiowa.edu/patents/136