Document Type

Patent

Patent Number

US Patent 4,134,997

Patent agency

United States Patent and Trademark Office

Publication Date

1-16-1979

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

05/773,353

Date Filed

1977-03-01

Total Pages

5 pages

Abstract

The compounds represented by the structural formulae: ##STR1## one each used for the treatment of warm blooded mammals with infarcted hearts.The compounds I and II have a totally unpredictable effect on the infarcted heart. An artificial infarct (stoppage of blood vessel) is produced, to mimic the occurrence of a heart attack. Administration of a suitable amount of the compound opens new blood channels in the heart tissue, by-passing the infarcted region, and providing a supply of arterial blood to the area served by the occluded blood vessel. The necrosis which normally occurs in regions of the heart muscle as a result of a stoppage of an artery and resultant oxygen deficiency is largely prevented.

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URL

https://ir.uiowa.edu/patents/14