US Patent 4,134,997
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The compounds represented by the structural formulae: ##STR1## one each used for the treatment of warm blooded mammals with infarcted hearts.The compounds I and II have a totally unpredictable effect on the infarcted heart. An artificial infarct (stoppage of blood vessel) is produced, to mimic the occurrence of a heart attack. Administration of a suitable amount of the compound opens new blood channels in the heart tissue, by-passing the infarcted region, and providing a supply of arterial blood to the area served by the occluded blood vessel. The necrosis which normally occurs in regions of the heart muscle as a result of a stoppage of an artery and resultant oxygen deficiency is largely prevented.
Cannon, Joseph G.; Long, John P.; and Diana, John N. Effect of an aminotetralin derivative on coronary blood flow in infarcted hearts. US Patent 4,134,997 filed March 01, 1977 and issued January 16, 1979. https://ir.uiowa.edu/patents/14