US Patent 5,462,857
United States Patent and Trademark Office
University of Iowa Research Foundation (Oakdale, IA, US)
The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
Campbell, Kevin P.; Knudson, Michael C.; Kahl, Steven D.; Louis, Charles F.; and Mickelson, James R. Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor. US Patent 5,462,857 filed August 09, 1993 and issued October 31, 1995. https://ir.uiowa.edu/patents/142