Document Type

Patent

Patent Number

US Patent 5,462,857

Patent agency

United States Patent and Trademark Office

Publication Date

10-31-1995

Assignee

University of Iowa Research Foundation (Oakdale, IA, US)

Application Number

08/104,330

Date Filed

1993-08-09

Total Pages

13 pages

Abstract

The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.

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URL

https://ir.uiowa.edu/patents/142