US Patent 5,490,098
United States Patent and Trademark Office
University of Iowa Research Foundation (Oakdale, IA, US)
An automated system and method for determining pupillary threshold response is described. The system achieves the determination of pupillary threshold levels through the measurement of supra-threshold responses at varying light intensities, which measured values are processed by a non-linear regression routine to approximate threshold response. The system takes supra-threshold measurements by means of a computerized pupillometer which is linked to an automated perimeter. The measurements are sequentially taken at varied light intensities which are reiteratively selected in response to the comparison between responses that have been previously measured during the test and a pre-stored response curve of expected values. The measured values are then processed by a non-linear regression routine to indirectly generate an estimated threshold level. The system is fully automated, produces accurate and reliable results, and is not subject to the uncertainties which are attendant with the measurement of threshold levels by the taking of subjective measurements.
Kardon, Randy H. Automated system and method for determining pupillary threshold response. US Patent 5,490,098 filed February 10, 1994 and issued February 06, 1996. https://ir.uiowa.edu/patents/145