Document Type

Patent

Patent Number

US Patent 5,491,133

Patent agency

United States Patent and Trademark Office

Publication Date

2-13-1996

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

07/672,088

Date Filed

1991-03-19

Total Pages

14 pages

Abstract

The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.

Share

COinS
 

URL

https://ir.uiowa.edu/patents/146