Document Type

Patent

Patent Number

US Patent 5,569,600

Patent agency

United States Patent and Trademark Office

Publication Date

10-29-1996

Assignee

Massachusetts Institute of Technology (Cambridge, MA) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

08/378,789

Date Filed

1995-01-26

Total Pages

18 pages

Abstract

A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Monoclonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.

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URL

https://ir.uiowa.edu/patents/154