US Patent 5,708,957
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
An optical sensor is disclosed which uses a radioluminescent light source to supply the incident radiation for detecting a selected substance in a test medium. The radioluminescent source includes a beta emitting radio isotope which energizes a co-immobilized luminophore to release light in a given wavelength for a chemical sensor operation. The radioluminescent source is coupled with a sensing matrix for detecting and quantifying the analyte of interest. The sensing matrix produces a characteristic signal based on either absorbance or fluorescence which varies according to the concentration of the selected analyte in the sample. A photodetector measures the resulting optical signal from which the analyte concentration is determined.
Chuang, Han and Arnold, Mark A. Optical sensor with radioluminescent light source. US Patent 5,708,957 filed February 02, 1996 and issued January 13, 1998. https://ir.uiowa.edu/patents/175