US Patent 5,734,040
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
This invention relates to oligonucleotides with ethylenediamine phosphoramidate internucleoside linkages useful for binding to eukaryotic duplex DNA to inhibit or alter gene expression.
Weeks, Daniel L. and Dagle, John Positively charged oligonucleotides as regulators of gene expression. US Patent 5,734,040 filed March 21, 1996 and issued March 31, 1998. https://ir.uiowa.edu/patents/181