US Patent 5,789,450
United States Patent and Trademark Office
University of Iowa Research Foundation (Oakdale, IA, US)
Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.
Baker, Max T. and Tinker, John H. Deuterated sevoflurane as an inhalational anesthetic. US Patent 5,789,450 filed February 15, 1995 and issued August 04, 1998. https://ir.uiowa.edu/patents/190