US Patent 5,935,936
United States Patent and Trademark Office
Genzyme Corporation (Cambridge, MA) ; University of Iowa (Iowa City, IA, US)
Novel compositions are provided. Typically, the compositions comprise one or more neutral co-lipids and also a cationic amphiphile. Therapeutic compositions are prepared according to the practice of the invention by contacting a therapeutically active molecule with a dispersion of neutral co-lipid(s) and amphiphile(s).
Fasbender, Allen J.; Welsh, Michael J.; Siegel, Craig S.; Lee, Edward R.; Chang, Chau-dung; Marshall, John; Cheng, Seng H.; Harris, David J.; Eastman, Simon J.; Hubbard, Shirley C.; Lane, Mathieu B.; Rowe, Eric A.; Scheule, Ronald K.; and Yew, Nelson S. Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules. US Patent 5,935,936 filed June 03, 1996 and issued August 10, 1999. https://ir.uiowa.edu/patents/218