US Patent 5,939,393
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A bactericidal factor isolated from the surface fluid of airway epithelial cells and uses therefore is described. The bactericidal factor is characterized as having the following features: a) a molecular weight of less than 10 kd; b) heat stable; c) broad spectrum activity including gram positive and gram negative bacteria, fungi, and methicillin resistant Staphylococcus; and d) decreased antimicrobial activity in increasing salt concentration.
Welsh, Michael J.; Smith, Jeffrey J.; Travis, Sue M.; and Greenberg, Everett P. Bactericidal factor in human airway surface fluid and uses thereof. US Patent 5,939,393 filed April 17, 1997 and issued August 17, 1999. https://ir.uiowa.edu/patents/219