US Patent 5,958,907
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
Pharmaceutical compositions comprising an inorganic pyrophosphate (PPi) in a form that renders the PPi accessible to ABC proteins when administered to a subject in vivo, as well as use of the compositions for treating subjects having a disease or disorder associated with inappropriate or inadequate ABC protein activity (e.g., cystic fibrosis, multi drug resistance, Zellweger's Syndrome) is disclosed.
Welsh, Michael J. Pharmaceutical compositions and uses of inorganic pyrophosphates. US Patent 5,958,907 filed August 29, 1997 and issued September 28, 1999. https://ir.uiowa.edu/patents/222