US Patent 5,962,425
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
Walder, Joseph A.; Walder, Roxanne Y.; Eder, Paul S.; and Dagle, John M. Methods for decreasing the expression of specifically targeted genes. US Patent 5,962,425 filed June 02, 1995 and issued October 05, 1999. https://ir.uiowa.edu/patents/224