Document Type

Patent

Patent Number

US Patent 5,962,425

Patent agency

United States Patent and Trademark Office

Publication Date

10-5-1999

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

08/460,704

Date Filed

1995-06-02

Total Pages

16 pages

Abstract

The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.

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URL

https://ir.uiowa.edu/patents/224