US Patent 5,962,429
United States Patent and Trademark Office
University of Iowa (Iowa City, IA, US)
The present invention provides noncovalent complexes of cationic molecules and adenoviral vectors containing a transgene. The complexes of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the complexes are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to a CF patient utilizing a complex of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.
Welsh, Michael J. and Fasbender, Allen J. Complexes of adenovirus with cationic molecules. US Patent 5,962,429 filed November 22, 1996 and issued October 05, 1999. https://ir.uiowa.edu/patents/225