Document Type

Patent

Patent Number

US Patent 6,028,061

Patent agency

United States Patent and Trademark Office

Publication Date

2-22-2000

Assignee

Children's Medical Center Corp (Boston, MA) ; University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/099,296

Date Filed

1998-06-18

Total Pages

12 pages

Abstract

The present invention is based on the unexpected discovery that a molecule having as its major repeating units N-acetylglucosamine alternating in sequence with 2-O-sulfated uronic acid, inhibits FGF mitogenicity, and thus is useful in inhibiting angiogenesis. Additionally, the molecule has low toxicity and inhibits FGF mitogenicity without affecting anticoagulant activity. One preferred molecule is a glycosaminoglycan such as archaran sulfate. The molecules are in pharmaceutical compositions that can be used in the treatment of diseases which are angiogenesis-dependent.

Share

COinS
 

URL

https://ir.uiowa.edu/patents/234