US Patent 6,028,061
United States Patent and Trademark Office
Children's Medical Center Corp (Boston, MA) ; University of Iowa Research Foundation (Iowa City, IA, US)
The present invention is based on the unexpected discovery that a molecule having as its major repeating units N-acetylglucosamine alternating in sequence with 2-O-sulfated uronic acid, inhibits FGF mitogenicity, and thus is useful in inhibiting angiogenesis. Additionally, the molecule has low toxicity and inhibits FGF mitogenicity without affecting anticoagulant activity. One preferred molecule is a glycosaminoglycan such as archaran sulfate. The molecules are in pharmaceutical compositions that can be used in the treatment of diseases which are angiogenesis-dependent.
Bernfield, Merton; Kim, Yeong Shik; and Linhardt, Robert J. Angiogenesis inhibitors and use thereof. US Patent 6,028,061 filed June 18, 1998 and issued February 22, 2000. https://ir.uiowa.edu/patents/234