US Patent 6,057,288
United States Patent and Trademark Office
University of Iowa (Iowa City, IA, US) ; University of Rochester (Rochester, NY, US) ; Ithaca College (Ithaca, NY, US)
Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.
Pearson, James P.; Gray, Kendall M.; Passador, Luciano; Tucker, Kenneth D.; Eberhard, Anatol; Iglewski, Barbara H.; and Greenberg, Everett P. Autoinducer molecule. US Patent 6,057,288 filed June 01, 1995 and issued May 02, 2000. https://ir.uiowa.edu/patents/236