US Patent 6,061,582
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US) ; Ohio University (Athens, OH)
Non-invasive measurements of physiological chemicals such as glucose in a test subject are made using infrared radiation and a signal processing system. The level of a selected physiological chemical in the test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near infrared radiation; (b) collecting data concerning the irradiated light on the test subject; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiolgocial chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The collected data is in the form of either an absorbance spectrum or an interferogram.
Small, Gary W. and Arnold, Mark Method and apparatus for non-invasive determination of physiological chemicals, particularly glucose. US Patent 6,061,582 filed June 11, 1997 and issued May 09, 2000. https://ir.uiowa.edu/patents/237