Inventor

Michael J. Welsh

Document Type

Patent

Patent Number

US Patent 6,086,870

Patent agency

United States Patent and Trademark Office

Publication Date

7-11-2000

Assignee

University of Iowa Research Foundation (Iowa City, IA, US)

Application Number

09/082,510

Date Filed

1998-05-21

Total Pages

21 pages

Abstract

The present invention provides co-precipitates of metal salts and adenoviral vectors containing a transgene. The co-precipitates of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the co-precipitates are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to an individual with CF utilizing a co-precipitate of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.

Share

COinS
 

URL

https://ir.uiowa.edu/patents/240