US Patent 6,159,735
United States Patent and Trademark Office
University of Iowa Research Foundation (Iowa City, IA, US)
A DNA element which was isolated from the upstream regulatory region of the CT/CGRP gene and which exhibits cell-specific enhancement of transcription is described. The enhancer activity of the element is further regulated by members of the superfamily of steroids and retinoids which increase or decrease transcription in a cell-specific manner. Methods of gene regulation and therapeutic uses involving the DNA element are also described. Furthermore, proteins which bind to the element and regulate transcription of genes under the control of the DNA element are also described. These proteins can be used for purposes of regulation of gene expression.
Russo, Andrew F.; Lanigan, Thomas M.; and Tverberg, Lois A. Calcitonin/calcitonin gene related peptide enhancer element and associated DNA binding proteins. US Patent 6,159,735 filed June 01, 1995 and issued December 12, 2000. https://ir.uiowa.edu/patents/251