Document Type

Patent

Patent Number

US Patent 6,194,388

Patent agency

United States Patent and Trademark Office

Publication Date

2-27-2001

Assignee

University of Iowa Research Foundation (Iowa City, IA, US) ; The United States of America (Washington, DC, US) ; Coley Pharmaceutical Group

Application Number

08/386,063

Date Filed

1995-02-07

Total Pages

23 pages

Abstract

Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.

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URL

https://ir.uiowa.edu/patents/258